The principal cytochrome P450 isoenzyme involved appears to get CYP2E1, with CYP1A2 and CYP3A4 as added pathways. Close to eighty five% of the oral dose seems within the urine within 24 hours of administration, most because the glucuronide conjugate, with modest amounts of other conjugates and unchanged drug [see OVERDOSAGE] for toxicity details.Ra